Crystal Structure of Chaperonin, 1pcq Template:STRUCTURE 1pcq
Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia .
The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus . The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya.
3D Structures of Chaperonin Updated on 20-November-2014
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Group I Large subunit 3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis 1sjp , 3rtk – MtGroEL2 residues 42-5393fbh , 2eu1 , 1j4z , 1kpo , 1oel , 1grl , 2yey – EcGroEL (mutant) - Escherichia coli 3e76 , 2nwc , 1xck , 1ss8 , 4hel – EcGroEL3c9v , 3cau , 2ynj – EcGroEL – Cryo EM2c7e , 1gr5 , 4aaq - EcGroEL (mutant) – Cryo EM1dk7 - EcGroEL apical domain1fy9 , 1fya , 1kid , 1jon , 3vz6 , 3vz7 , 3vz8 – EcGroEL apical domain (mutant) 1srv – TtCPN60 apical domain - Thermus thermophilus 3osx - CPN60 apical domain – Xenorhabdus nematophila 1iok – CPN60 – Paracoccus denitrificans Large subunit binary complex 1kp8 - EcGroEL (mutant) + ATP4aar , 4aas , 4aau , 4ab2 , 4ab3 - EcGroEL (mutant) + ATP – Cryo EM1sx3 - EcGroEL + ATP1sx4 - EcGroEL + ADP4ki8 - EcGroEL (mutant) + ADP1mnf – EcGroEL + polypeptide2cgt – EcGroEL + capsid assbly protein GP31 – EM1dkd - EcGroEL apical domain + polypeptideSmall subunit 3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae 1wnr – TtCPN10 residues 1-941p3h , 1hx5 – MtCPN101p82 , 1p83 - MtCPN10 residues 1-25 - NMR1egs - GroES residues 19-27 - NMRLarge + small subunit 1svt , 1pcq - EcGroEL + GroES1pf9 , 1aon - EcGroEL + GroES + ADP2c7c , 2c7d - EcGroEL + GroES – Cryo EM1gru - EcGroEL + GroES + ATP + ADP – Cryo EM3zpz , 3zq0 , 3zq1 - EcGroEL + GroES + ADP – Cryo EM1we3 – TtCPN60 + CPN101wf4 - TtCPN60 + CPN10 + ADPGroup II 3izh , 3izi , 3izj , 3izk , 3izl , 3izm , 3izn , 3los , 3iyf , 3j3x – MmCPN – Methanococcus maripaludis – EM3kfb , 3kfe , 3kfk – MmCPN3j02 , 3j03 – MmCPN (mutant) – Cryo EM3ruq - MmCPN + ADP3rus - MmCPN (mutant) + ADP3ruw - MmCPN (mutant) + ADP-AlF33ruv - MmCPN (mutant) + ATP analogCCT Hsp33 See Heat Shock Proteins
Thermosome 1a6d - TaTherm α+β subunits – Thermoplasma acidophilum 1a6e - TaTherm α+β subunits + ADP1ass , 1asx - TaTherm α apical domain1e0r – TaTherm β apical domain3ko1 – AtTherm α subunit– Acidianus tengchongensis 3j1b , 3j1c , 3j1e - AtTherm α subunit – Cryo EM 3j1f - AtTherm β subunit + ATP – Cryo EM 3aq1 – Therm – Methanococcoides burtonii 1q2v , 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-11q3q - TkTherm α subunit (mutant) + AMP-PNP1q3s - TkTherm α subunit (mutant) + ADP1lep – CPN-10 – Mycobacterium leprae proteopedia link
