Cyclohydrolase

<StructureSection load='1wuq' size='340' side='right' caption='Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code 1wuq).' scene=>

Function

• GTP cyclohydrolase I catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis
• GTP cyclohydrolase II catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.
• IMP cyclohydrolase catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis
• Methenyltetrahydromethanopterin cyclohydrolase catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis

3D structures of cyclohydrolase

Updated on 20-November-2014

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• GTP cyclohydrolase I
  • 1gtp – EcGCH I – Escherichia coli
    
  • 3d1t – NgGCH IB + Zn – Neisseria gonorrhoeae
    
  • 3d2o – NgGCH IB + Mn
    
  • 1fb1 – hGCH I + Zn – human
    
  • 1wm9 – TtGCH I + Zn – Thermus thermophilus
    
• GTP cyclohydrolase I complexes
  • 1a8r, 1a9c, 1n3r, 1n3t, 1n3s – EcGCH I (mutant) + GTP
    
  • 4du6 – GCH I + GTP – Yersinia pseudotuberculosis
    
  • 1fbx – EcGCH I + Zn
    
  • 1wuq, 1wur – TtGCH I + Zn + 8-oxo-GTP
    
  • 1is7 – rGCH I + GCH feedback regulatory protein - rat
    
  • 1is8 – rGCH I + GCH feedback regulatory protein + Zn
    
  • 1wpl – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin
    
• GTP cyclohydrolase II
  • 2bz1 – EcGCH II + Zn
    
  • 2bz0 – EcGCH II + Zn + phosphomethylphosphonic acid guanylate
    
• GTP cyclohydrolase III
  • 2qv6 – GCH III + GTP + Ca – Methanocaldococcus jannaschii
    
• IMP cyclohydrolase
  • 2ntm – MtICH – Methanothermobacter thermoautotrophicus
    
  • 2ntk – MtICH + IMP
    
  • 2ntl – MtICH + AICAR
    
• Methenyltetrahydromethanopterin cyclohydrolase
  • 1qlm – MCH – Methanopyrus kandleri
    
  • 4gvr – AfMCH – Archaeoglobus fulgidus
    
  • 4gvq – AfMCH + tetrahydromethanopterin
    
  • 4gvs – AfMCH + N5-formyl-tetrahydromethanopterin
    
• Phosphoribosyl-ATP cyclohydrolase
  • 1zps – MtPCH + Cd
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky