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Function
• GTP cyclohydrolase I catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis
• GTP cyclohydrolase II catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.
• IMP cyclohydrolase catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis
• Methenyltetrahydromethanopterin cyclohydrolase catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis
Disease
Relevance
Structural highlights |
3D structures of cyclohydrolase
Updated on 20-November-2014
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- GTP cyclohydrolase I
- 1gtp – EcGCH I – Escherichia coli
- 3d1t – NgGCH IB + Zn – Neisseria gonorrhoeae
- 3d2o – NgGCH IB + Mn
- 1fb1 – hGCH I + Zn – human
- 1wm9 – TtGCH I + Zn – Thermus thermophilus
- GTP cyclohydrolase I complexes
- 1a8r, 1a9c, 1n3r, 1n3t, 1n3s – EcGCH I (mutant) + GTP
- 4du6 – GCH I + GTP – Yersinia pseudotuberculosis
- 1fbx – EcGCH I + Zn
- 1wuq, 1wur – TtGCH I + Zn + 8-oxo-GTP
- 1is7 – rGCH I + GCH feedback regulatory protein - rat
- 1is8 – rGCH I + GCH feedback regulatory protein + Zn
- 1wpl – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin
- GTP cyclohydrolase II
- 2bz1 – EcGCH II + Zn
- 2bz0 – EcGCH II + Zn + phosphomethylphosphonic acid guanylate
- GTP cyclohydrolase III
- 2qv6 – GCH III + GTP + Ca – Methanocaldococcus jannaschii
- IMP cyclohydrolase
- 2ntm – MtICH – Methanothermobacter thermoautotrophicus
- 2ntk – MtICH + IMP
- 2ntl – MtICH + AICAR
- Methenyltetrahydromethanopterin cyclohydrolase
- 1qlm – MCH – Methanopyrus kandleri
- 4gvr – AfMCH – Archaeoglobus fulgidus
- 4gvq – AfMCH + tetrahydromethanopterin
- 4gvs – AfMCH + N5-formyl-tetrahydromethanopterin
- Phosphoribosyl-ATP cyclohydrolase
References
