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Function
Geranylgeranyl transferase type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containg the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated.
Disease
Relevance
Structural highlights |
3D structures of eranylgeranyl transferase
Updated on 26-November-2014
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- Geranylgeranyl transferase type 1
- 1s64 – rGGT1 α+β subunits + inhibitor - rat
- 1n4p – rGGT1 α+β subunits + GGPP
- 1n4s, 1n4r – rGGT1 α+β subunits + GGPP + peptide-GG containing CAAX
- 1tnb, 1tno, 1tnu, 1tny, 1tnz, 1n4q – rGGT1 α+β subunits + GGPP analog + peptide containing CAAX
- 3dra – GGT1 α+β subunits + GGPP – Candida albicans
- Geranylgeranyl transferase type 2
- 1dce – rGGT2 α+β subunits – rat
- 3dss – rGGT2 α+β subunits
- Geranylgeranyl transferase type 2 complex
- 3c72, 3pz1, 3pz3, 4ehm, 4gts, 4gtt, 4gtv – rGGT2 α+β subunits + inhibitor
- 3hxb, 3hxc, 3hxd, 3hxe, 3hxf – rGGT2 α (mutant) +β subunits + inhibitor
- 1ltx – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl
- 3dst – rGGT2 α+β subunits + GGPP
- 3dsu – rGGT2 α+β subunits + farnesyl-PP
- 3dsv, 3dsw, 3dsx – rGGT2 α+β subunits + GG
- 3pz2 – rGGT2 α+β subunits + GGPP + inhibitor
References
