3epv | pdb_00003epv

X-ray Structure of the Metal-sensor CnrX in both the Apo- and Copper-bound Forms

spinqualitylabelsall models 3epv, resolution 1.74Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3epv is a 4 chain structure with sequence from Cupriavidus metallidurans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CU NonStd Res: MSE Gene: cnrR, cnrX, RMe0087, Rmet_6206 (Cupriavidus metallidurans) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Both the X-ray structures of the apo- and the copper-bound forms of the metal-sensor domain (residues 31-148) of CnrX from Cupriavidus metallidurans CH34 were obtained at 1.74A resolution from a selenomethionine derivative. This four-helix hooked-hairpin is the first structure of a metal-sensor in an ECF-type signaling pathway. The copper ion is bound in a type 2-like center with a 3N1O coordination in the equatorial plane and shows an unprecedented remote fifth axial ligand with Met93 contributing a weak S-Cu bond. The signal onset cannot be explained by conformational changes associated with CnrX metallation. X-ray structure of the metal-sensor CnrX in both the apo- and copper-bound forms.,Pompidor G, Maillard AP, Girard E, Gambarelli S, Kahn R, Coves J FEBS Lett. 2008 Nov 26;582(28):3954-8. Epub 2008 Nov 4. PMID:18992246 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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