Growth differentiation factor

<StructureSection load='3evs' size='350' side='right' caption='Structure of growth differentiation factor GDF-5 (green) complex with bone morphogenetic receptor (pink) (PDB entry 3evs)' scene=>

Growth differentiation factor (GDF) are proteins which function in development.

• GDF-2 maintains the response of cholinergic neurons to acetylcholine.
  
• GDF-5 is expressed in the central nervous system and is involved in the development of joints and skeleton.
  
• GDF-8 or myostatin, controls the growth of muscle tissue. For more details see Group:MUZIC:Myostatin.

3D structures of growth differentiation factor

Updated on 26-November-2014

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• GDF-2
  • 1zkz – hGDF – human
    
  • 4fao – hGDF + serine/threonine-protein kinase receptor + activin receptor
    
• GDF-5
  • 2bhk, 1waq – hGDF
    
  • 3evs – hGDF + bone morphogenetic receptor
    
  • 3qb4 – hGDF (mutant) + bone morphogenetic receptor
    
• GDF-8
  • 3hh2 – mGDF + follistatin – mouse
    
  • 3sek – mGDF + follistatin-related protein
    

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Michal Harel, Alexander Berchansky