Hyaluronidase

spinqualitylabelsall models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Hyaluronidase (HU) hydrolyzes complex carbohydrates such as hyaluronan which is part of the extracellular matrix. The hydrolysis increases tissue permeability. HU is used in medicine to speed drug delivery. Hyaluronic acid (HUA) is a popular dermal filler material. Superposition of the EGF-like domain of hyaluronidase-1 (yellow) and the heparin-binding EGF-like growth factor (light blue). The three disulfide bonds of the EGF domains (highlighted red) exhibit the same pattern in the primary structure and are located in similar positions in the 3D structure. Hyaluronidase cleaves the β1,4-glycosidic bond of the glycosaminoglycan hyaluronan

3D structures of hyaluronidase

Updated on 27-November-2014

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• Hyaluronidase
  • 1egu, 2brw – SpHU – Streptococcus pneumoniae
    
  • 1n7n, 1n7o, 1n7p – SpHU (mutant)
    
  • 1fcq, 1fcu – bHU – bee
    
  • 1f1s – SaHU – Streptococcus agalactiae
    
  • 2c3f, 2dp5, 2yw0, 2yx2, 2wb3, 2wh7 - SpyHU – Streptococcus pyogenes
    
  • 2cbi, 2w1q, 2w1s - CpHU – Clostridium perfringens
    
  • 2jnk - CpHU residues 1498-1628]] - NMR
    
  • 2atm - HU – Vespula vulgaris
    
  • 2pe4 – HU-1 – human
• Hyaluronidase binary complex
  • 1c82 – SpHU + HUA disaccharide
    
  • 1f9g – SpHU + ascorbate
    
  • 2brv– SpHU + malonate
    
  • 1fcv - bHU + HUA
    
  • 1i8q - SaHU + HUA disaccharide
    
  • 1loh, 1lxk - SpHU + glucuronic acid
    
  • 1n7q, 1n7r - SpHU (mutant) + glucuronic acid
    
  • 1lxm - SaHU + glucuronic acid
    
  • 1ojm, 1ojp - SpHU + condroitin disaccharide
    
  • 1ojn, 1ojo - SpHU (mutant) + condroitin disaccharide
    
  • 1w3y - SpHU + palmitoyl-vitamin C
    
  • 2cbj - CpHU + PugNac
    
  • 2j1a - CpHU + galactose
    
  • 2j1e - CpHU + LacNac
    
  • 2j7m, 2w1u, 2wdb - CpHU + carbohydrates
    
  • 2j62 - CpHU + GlcNac-statin
    
  • 2brp – SpHU + inbhibitor
    
  • 2j88 - bHU + FAB
    
  • 2yvv - SpyHU + lactose
    
  • 3eka - SpyHU + ascorbate
    

Reference

Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis., Chao KL, Muthukumar L, Herzberg O, Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. PMID:17503783

Created with the participation of Osnat Herzberg, Eran Hodis, Joel L. Sussman, Jaime Prilusky.

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Joel L. Sussman