Lactoferrin

Lactoferrin (LTF) is found in secretory fluids. It is a component of the immune system and has antimicrobial activity. LTF interacts with DNA, RNA, polysaccharides and heparin. LTF is inhibited by nonsteroidal anti-inflammatory drugs (NSAID) like aspirin. For detailed discussion of human lactoferrin see Human lactoferrin.

3D Structures of lactoferrin

Updated on 30-November-2014

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• Apo lactoferrin
  • 1i6b, 1b7u – hoLTF – horse
    
  • 1dtz – cLTF - camel
    
  • 1cb6, 1lfg, 1lfh – hLTF - human
    
  • 1u62, 1xv4, 1xv7, 1z6v, 1z6w - hLTF peptide – NMR
    
  • 1lfc – bLTF residues 17-41 – bovine – NMR
    
  • 1y58, 1y5c - bLTF residues 4-14 – NMR
    
  • 4oqo – bLTF C lobe
    
• Lactoferrin
  • 1blf – bLTF + 2Fe
    
  • 1sdx - bLTF C lobe + 3Zn
    
  • 1nkx, 3u8q - bLTF C lobe + 2Zn + Fe
    
  • 1b1x, 1f9b – hoLTF + 2Fe
    
  • 1qjm – hoLTF + 2Sm
    
  • 1ce2, 1biy – buLTF + 2Fe - buffalo
    
  • 1i6q – cLTF + 2Fe
    
  • 2bjj, 1sqy, 1n76– hLTF + 2Fe
    
  • 1b0l - hLTF (mutant) + 2Fe
    
  • 1fck – hLTF + 2Ce
    
  • 1lfi - hLTF + 2Cu
    
  • 1lct - hLTF N lobe + 2Fe
    
  • 1h43, 1h44, 1h45, 1l5t, 1eh3, 1vfd, 1vfe, 1hse, 1dsn - hLTF N lobe (mutant) + 2Fe
    
  • 1jw1 – LTF + 2Fe – goat
• Lactoferrin binary complex
  • 3sdf – bLTF C lobe + lipoteichoic acid + 2Zn + Fe
    
  • 4n6p - bLTF C lobe + meclofenamic acid + 2Zn + Fe
    
  • 4ned - bLTF C lobe + fenoprofen + 2Zn + Fe
    
  • 3rgy - bLTF C lobe + lipopolysaccharide + Zn + Fe
    
  • 3kj7, 3k0v, 2q8j, 2o51, 2nwj, 2dxy, 2dwj, 2dsf, 2ds9, 2hca, 2dqv, 2dp8, 2g93, 2ays, 2alu, 2dwi, 2dyx, 2o1l, 2p1s - bLTF C lobe + polysaccharide + 2Zn + Fe
    
  • 2o1l - bLTF C lobe + polysaccharide + Zn + Fe
    
  • 2fa7, 2b65 - bLTF C lobe + polysaccharide + 3Zn + Fe
    
  • 2dvc, 2dwa, 2dwh, 2e0s, 2e1s, 2h4i, 2px1 - bLTF C lobe + saccharide + 2Zn + Fe
    
  • 2dxr - bLTF C lobe + sorbitol+ 2Zn + Fe
    
  • 3iaz, 3ib0, 3ib1 - bLTF C lobe (mutant) + NSAID + 2Zn + Fe
    
  • 3e9x, 2qje, 2zmb, 3crb, 2nuv, 4fim, 4fjp, 4for, 4g2z, 4g77, 4g8h, 4grk, 3taj - bLTF C lobe + NSAID + 2Zn + Fe
    
  • 3o97, 3mjn, 3cfl, 2ocu, 3tod, 3tus – bLTF C lobe + inhibitor + 2Zn + Fe
    
  • 3ib2 - bLTF C lobe (mutant) + inhibitor + 2Zn + Fe
    
  • 2doj - bLTF C lobe + adenosine + 2Zn + Fe
    
  • 3ugw - bLTF C lobe + deoxycytidine + 2Zn + Fe
    
  • 3ci8 - bLTF C lobe + niacin + 2Zn + Fe
    
  • 2r9j - bLTF C lobe + nicotinamide + 2Zn + Fe
    
  • 2r71 - bLTF C lobe + inositol + 2Zn + Fe
    
  • 3uk4 - bLTF C lobe + pentatriol + 2Zn + Fe
    
  • 3usd - bLTF C lobe + pyridine derivative + 2Zn + Fe
    
  • 3ttr - bLTF C lobe + anasthetic + 2Zn + Fe
    
  • 3vdf - bLTF C lobe + diaminopimelic acid + 2Zn + Fe
    
  • 4dxu - bLTF C lobe + caproic acid + 2Zn + Fe
    
  • 3v5a - bLTF C lobe + γ-amino butyric acid + 2Zn + Fe
    
  • 3u72, 4dig - bLTF C lobe + polypeptide + 2Zn + Fe
    
  • 3ptl – bLTF peptide + proteinase K
    
  • 1bjr - buLTF peptide + proteinase K
    
  • 1b7z - hoLTF + 2Fe + oxalate
    
  • 3cr9 – hoLTF + inhibitor + 2Fe
    
  • 2j4u – cLTF N terminal + OMPC
    
  • 1bka - hLTF + 2Fe + oxalate
    
  • 1lcf - hLTF + 2Cu + oxalate
    
  • 2pms – hLTF N lobe + PSPA transferring-binding domain + 2Zn + 2Fe
    

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