Nitroreductase

Nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO₂ group. The NO₂ group is reduced to hydroxylamine. NR use FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. The NR is of special interest due to its potential use as activator of prodrugs in cancer therapy.

3D structures of nitroreductase

Updated on 01-December-2014

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• Nitroreductase
  • 1f5v, 1oo5 – EcNR – Escherichia coli
    
  • 3bm1, 1ds7 – EcNR minimal
    
  • 3bm2 – EcNR minimal -FMN
    
  • 1nec, 1kqd – EclNR – Enterobacter cloacae
    
  • 1ywq, 2i7h – NR – Bacillus cereus
    
  • 2b67 – NR – Streptococcus pneumonia
    
  • 3ek3, 3hoi – NR – Bacterioides fragilis
    
  • 3g14 – NR – Clostridium novyi
    
  • 3h4o, 3koq - NR – Clostridium difficile
    
  • 3gr3 – NR – Bartonella henselae
    
  • 3hzn – NR – Salmonella typhimurium
    
  • 3k6h – NR – Agrobacterium tumefaciens
    
  • 2wqf – NR – Lactococcus lactis
    
  • 2wzv, 2ymv – MsNR – Mycobacterium smegmatis
    
  • 3of4 – NR FMN/FAD – Idiomarina loihiensis
    
  • 3n2s – NR – Bacillus subtilis
    
  • 3pxv – NR – Desulfitobacterium hafniense
    
  • 3qdl – NR – Helicobacter pylori
    
  • 3r5l, 3r5p - MtNR – Mycobacterium tuberculosis
    
  • 3r5r, 3r5w – MtNR F420
• Nitroreductase binary complex
  • 1kqb – EclNR + benzoate
    
  • 1kqc – EclNR + acetate
    
  • 1ylr, 1ylu - EcNR + acetate
    
  • 1icr, 1icu, 1icv – EcNR + nicotinic acid
    
  • 1ooq – EcNR + dicoumarol
    
  • 1oo6, 1oon, 1idt – EcNR + benzamide derivative
    
  • 1yki – EcNR + antibiotic
    
  • 2wzw - MsNR + NADPH

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