Plasminogen

Plasmin (PLN) is a serine protease which is involved in degradation of fibrin clots. PLN is released as the zymogen plasminogen (PLG) which is converted to the active PLN by a variety of enzymes. PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.

3D Structures of plasminogen

Updated on 03-December-2014

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• Plasminogen
  • 4dur, 4duu, 4a5t – hPLG 2
• Plasminogen kringle 1
  • 1pkr - hPLG kringle 1 – human
    
  • 1cea - hPLG kringle 1 + e-aminocaprioic acid
    
  • 1hpj, 1hpk - hPLG kringle 1 + 6-aminohexanoic acid - NMR
    
  • 1ceb - hPLG kringle 1 + AMCHA
• Plasminogen kringle 2
  • 1b2i - hPLG kringle 2 (mutant) – NMR
    
  • 1i5k - hPLG kringle 2 (mutant) + M2 protein peptide
    
  • 2kj4 – hPLG kringle 2 + M2 protein peptide – NMR
    
• Plasminogen kringle 3
  • 2l0s - hPLG kringle 3 – NMR
    
• Plasminogen kringle 4
  • 1pk4, 1pmk, 1pml, 1krn – hPLG kringle 4
    
  • 2pk4 - hPLG kringle 4 + e-aminocaprioic acid
• Plasminogen kringle 5
  • 5hpg - hPLG kringle 5
    
  • 2knf - hPLG kringle 5 – NMR
    
• Plasminogen catalytic domain
  • 1qrz, 1ddj, 1rjx – hPLG catalytic domain (mutant)
    
  • 1l4d, 1l4z - hPLG catalytic domain (mutant) + streptokinase α domain
• Plasmin
  • 1bml – hPLN catalytic domain + streptokinase
    
  • 1bui – hPLN light chain + staphylokinase
• Microplasmin
  • 3uir – hPLN + textilinin-1
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman