3mwt | pdb_00003mwt

Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+

spinqualitylabelsall models 3mwt, resolution 1.98Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3mwt is a 3 chain structure with sequence from Lassa virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MN, ZN Related: 3mwp, 3mx2, 3mx5 Gene: N, nucleoprotein (Lassa virus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Lassa virus, the causative agent of Lassa fever, causes thousands of deaths annually and is a biological threat agent, for which there is no vaccine and limited therapy. The nucleoprotein (NP) of Lassa virus has essential roles in viral RNA synthesis and immune suppression, the molecular mechanisms of which are poorly understood. Here we report the crystal structure of Lassa virus NP at 1.80 A resolution, which reveals amino (N)- and carboxy (C)-terminal domains with structures unlike any of the reported viral NPs. The N domain folds into a novel structure with a deep cavity for binding the m7GpppN cap structure that is required for viral RNA transcription, whereas the C domain contains 3'-5' exoribonuclease activity involved in suppressing interferon induction. To our knowledge this is the first X-ray crystal structure solved for an arenaviral NP, which reveals its unexpected functions and indicates unique mechanisms in cap binding and immune evasion. These findings provide great potential for vaccine and drug development. Cap binding and immune evasion revealed by Lassa nucleoprotein structure.,Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang Y, Dong C Nature. 2010 Nov 17. PMID:21085117 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein

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