3ndb | pdb_00003ndb

Crystal structure of a signal sequence bound to the signal recognition particle

spinqualitylabelsall models 3ndb, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3ndb is a 3 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PO4 Related: 2v3c Gene: MJ1034, srp19 (Methanocaldococcus jannaschii), MJ0101, srp54 (Methanocaldococcus jannaschii) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The signal recognition particle (SRP) recognizes and binds the signal sequence of nascent proteins as they emerge from the ribosome. We present here the 3.0-A structure of a signal sequence bound to the Methanococcus jannaschii SRP core. Structural comparison with the free SRP core shows that signal-sequence binding induces formation of the GM-linker helix and a 180 degrees flip of the NG domain-structural changes that ensure a hierarchical succession of events during protein targeting. Structural basis of signal-sequence recognition by the signal recognition particle.,Hainzl T, Huang S, Merilainen G, Brannstrom K, Sauer-Eriksson AE Nat Struct Mol Biol. 2011 Mar;18(3):389-91. Epub 2011 Feb 20. PMID:21336278 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Signal recognition particle protein

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