3sit | pdb_00003sit

Crystal structure of porcine CRW-8 Rotavirus VP8* in complex with aceramido-GM3

spinqualitylabelsall models 3sit, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3sit is a 2 chain structure with sequence from Porcine rotavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GLC, MRD, NA, GAL NonStd Res: SIA Related: 2i2s, 3sis Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Rotaviruses ubiquitously infect children under the age of 5, being responsible for more than half a million diarrhoeal deaths each year worldwide. Host cell oligosaccharides containing sialic acid(s) are critical for attachment by rotaviruses. However, to date, no detailed three-dimensional atomic model showing the exact rotavirus interactions with these glycoconjugate receptors has been reported. Here, we present the first crystallographic structures of the rotavirus carbohydrate-recognizing protein VP8() in complex with ganglioside G(M3) glycans. In combination with assessment of the inhibition of rotavirus infectivity by N-acetyl and N-glycolyl forms of this ganglioside, our results reveal key details of rotavirus-ganglioside G(M3) glycan recognition. In addition, they show a direct correlation between the carbohydrate specificities exhibited by VP8() from porcine and by monkey rotaviruses and the respective infectious virus particles. These novel results also indicate the potential binding interactions of rotavirus VP8() with other sialic acid-containing gangliosides. Novel Structural Insights into Rotavirus Recognition of Ganglioside Glycan Receptors.,Yu X, Coulson BS, Fleming FE, Dyason JC, von Itzstein M, Blanchard H J Mol Biol. 2011 Sep 17. PMID:21945555 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat protein

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