3rrk | pdb_00003rrk

Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase

spinqualitylabelsall models 3rrk, resolution 2.64Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3rrk is a 1 chain structure with sequence from Meiothermus ruber. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NHE, SO4 Gene: Mrub_0956 (Meiothermus ruber) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Subunit "a" is associated with the membrane-bound (V(0)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery. It has also been shown recently to be involved in diverse membrane fusion/secretory functions independent of acidification. Here, we report the crystal structure of the N-terminal cytosolic domain from the Meiothermus ruber subunit "I" homolog of subunit a. The structure is composed of a curved long central alpha-helix bundle capped on both ends by two lobes with similar alpha/beta architecture. Based on the structure, a reasonable model of its eukaryotic subunit a counterpart was obtained. The crystal structure and model fit well into reconstruction densities from electron microscopy of prokaryotic and eukaryotic vacuolar H(+)-ATPases, respectively, clarifying their orientations and interactions and revealing features that could enable subunit a to play a role in membrane fusion/secretion. Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase.,Srinivasan S, Vyas NK, Baker ML, Quiocho FA J Mol Biol. 2011 Jul 22. PMID:21787787 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also ATPase

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