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RmlC is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human.
Function
Disease
Relevance
Inhibitors of RmlC can serve as potential antimicrobial drugs.
Structural highlights |
3D structures of RmlC
Updated on 09-December-2014
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- RmlC
- 1pm7, 1upi – MtRmlC – Mycobacterium tuberculosis
- 2ixj, 1rtv – PaRmlC – Pseudomonas aeruginosa
- 1nxm – SsRmlC – Streptococcus suis
- 1ep0 – MetRmlC – Methanothermobacter thermautotrophicus
- 1dzr – StRmlC – Salmonella typhimurium
- RmlC complexes
- 2ixc – MtRmlC + dTDP rhamnose
- 2ixh – PaRmlC + dTDP rhamnose
- 2ixl – SsRmlC + dTDP rhamnose
- 2ixk – PaRmlC + dTDP-keto rhamnose
- 1nyw – SsRmlC + dTDP glucose
- 1nzc – SsRmlC + dTDP xylose
- 1epz – MetRmlC + TDP
- 3ryk – RmlC + TDP + pyrophosphate – Bacillus anthracis
- 1dzt – StRmlC + acetylthymidine diphosphate
References
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