2v7e | pdb_00002v7e
CRYSTAL STRUCTURE OF COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1), UNLIGANDED
|
Overview
Coactivator-associated arginine methyltransferase (CARM1) is a, transcriptional coactivator that methylates Arg17 and Arg26 in histone H3., CARM1 contains a conserved protein arginine methyltransferase (PRMT), catalytic core flanked by unique pre- and post-core regions. The crystal, structures of the CARM1 catalytic core in the apo and holo states reveal, cofactor-dependent formation of a substrate-binding groove providing a, specific access channel for arginine to the active site. The groove is, supported by the first eight residues of the post-core region, (C-extension), not present in other PRMTs. In vitro methylation assays, show that the C-extension is essential for all histone H3 methylation, activity, whereas the pre-core region is required for methylation of, Arg26, but not Arg17. ... [(full description)]
About this Structure
2V7E is a [Single protein] structure of sequence from [Mus musculus] with HG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase., Yue WW, Hassler M, Roe SM, Thompson-Vale V, Pearl LH, EMBO J. 2007 Sep 20;. PMID:17882261
Page seeded by OCA on Tue Oct 30 17:53:17 2007
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Mus musculus
- Single protein
- Hassler, M.
- Pearl, L.H.
- Roe, S.M.
- Thompson-Vale, V.
- Yue, W.W.
- HG
- Alternative splicing
- Arginine methyltransferase
- Chromatin regulator
- Co- activator
- Cytoplasm
- Histone modification
- Methyltransferase
- Nucleus
- S-adenosyl-l-methionine
- Transcription
- Transcription regulation
- Transferase
