3s2p | pdb_00003s2p

Crystal structure of CDK2 with a 2-aminopyrimidine compound

spinqualitylabelsall models 3s2p, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3s2p is a 1 chain structure with sequence from Thermomicrobium roseum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PMU Gene: CDK2 (Thermomicrobium roseum) Activity: Cyclin-dependent kinase, with EC number 2.7.11.22 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities. Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.,Lee J, Kim KH, Jeong S Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. Epub 2011 May 27. PMID:21684737 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cell division protein kinase 2

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