3shj | pdb_00003shj

Proteasome in complex with hydroxyurea derivative HU10

spinqualitylabelsall models 3shj, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3shj is a 28 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: H10, MES Related: 1ryp Activity: Proteasome endopeptidase complex, with EC number 3.4.25.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Inhibitors with a new mechanism of action are needed for 20S proteasome (CP) inhibition owing to the ineffectiveness of current market drugs against some types of solid tumors. A novel class of nonpeptidic CP inhibitors has been developed, which display reversible and noncovalent binding. The structure-based design of these highly active and site-specific inhibitors revealed unexplored binding subpockets. Hydroxyureas as Noncovalent Proteasome Inhibitors.,Gallastegui N, Beck P, Arciniega M, Huber R, Hillebrand S, Groll M Angew Chem Int Ed Engl. 2011 Nov 21. doi: 10.1002/anie.201106010. PMID:22105886 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Proteasome

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