3tam | pdb_00003tam

Crystal structure of HIV-1 reverse transcriptase (K103N mutant) in complex with inhibitor M06

spinqualitylabelsall models 3tam, resolution 2.51Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3tam is a 2 chain structure with sequence from Hiv-1 m:b_hxb2r. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: M06 Related: 3t19, 3t1a Gene: gag-pol, HIV-1 (HIV-1 M:B_HXB2R) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constraint to replace the aryl ether core of MK-4965 (1) and the more rigid indazole constraint of MK-6186 (2). The resulting pyridone compounds are potent inhibitors of HIV RT and have antiviral activity in cell culture that is superior to other next generation NNRTI's. Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.,Gomez R, Jolly S, Williams T, Tucker T, Tynebor R, Vacca J, McGaughey G, Lai MT, Felock P, Munshi V, DeStefano D, Touch S, Miller M, Yan Y, Sanchez R, Liang Y, Paton B, Wan BL, Anthony N Bioorg Med Chem Lett. 2011 Dec 15;21(24):7344-50. Epub 2011 Oct 17. PMID:22071300 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Reverse transcriptase

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