3t8s | pdb_00003t8s

Apo and InsP3-bound Crystal Structures of the Ligand-Binding Domain of an InsP3 Receptor

spinqualitylabelsall models 3t8s, resolution 3.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3t8s is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: I3P Gene: Insp3r, Itpr1 (Rattus norvegicus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed We report the crystal structures of the ligand-binding domain (LBD) of a rat inositol 1,4,5-trisphosphate receptor (InsP(3)R) in its apo and InsP(3)-bound conformations. Comparison of these two conformations reveals that LBD's first beta-trefoil fold (beta-TF1) and armadillo repeat fold (ARF) move together as a unit relative to its second beta-trefoil fold (beta-TF2). Whereas apo LBD may spontaneously transition between gating conformations, InsP(3) binding shifts this equilibrium toward the active state. Apo and InsP(3)-bound crystal structures of the ligand-binding domain of an InsP(3) receptor.,Lin CC, Baek K, Lu Z Nat Struct Mol Biol. 2011 Sep 4. doi: 10.1038/nsmb.2112. PMID:21892169 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Inositol 1%2C4%2C5-Trisphosphate Receptor

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