4ay2 | pdb_00004ay2

Capturing 5' tri-phosphorylated RNA duplex by RIG-I

spinqualitylabelsall models 4ay2, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ay2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ADP, MG, ZN NonStd Res: GTP Related: 2ykg Activity: RNA helicase, with EC number 3.6.4.13 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Retinoic acid inducible gene-I (RIG-I) is a key intracellular immune receptor for pathogenic RNAs, particularly from RNA viruses. Here, we report the crystal structure of human RIG-I bound to a 5' triphosphorylated RNA hairpin and ADP nucleotide at 2.8 A resolution. The RNA ligand contains all structural features that are essential for optimal recognition by RIG-I, as it mimics the panhandle-like signatures within the genome of negative-stranded RNA viruses. RIG-I adopts an intermediate, semiclosed conformation in this product state of ATP hydrolysis. The structure of this complex allows us to visualize the first steps in RIG-I recognition and activation upon viral infection. Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I.,Luo D, Kohlway A, Vela A, Pyle AM Structure. 2012 Nov 7;20(11):1983-8. doi: 10.1016/j.str.2012.08.029. Epub 2012, Sep 27. PMID:23022350 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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