3vr8 | pdb_00003vr8

Mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascaris suum

spinqualitylabelsall models 3vr8, resolution 2.81Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3vr8 is a 8 chain structure with sequence from Ascaris suum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EPH, F3S, FAD, FES, HEM, MLI, RQX, SF4 Related: 3vrb Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed In the anaerobic respiratory chain of the parasitic nematode Ascaris suum, complex II couples the reduction of fumarate to the oxidation of rhodoquinol, a reverse reaction catalyzed by mammalian complex II. In this study, the first structure of anaerobic complex II of mitochondria was determined. The structure, composed of four subunits and five co-factors, is similar to that of aerobic complex II, except for an extra peptide found in the smallest anchor subunit of the A. suum enzyme. We discuss herein the structure-function relationship of the enzyme and the critical role of the low redox potential of rhodoquinol in the fumarate reduction of A. suum complex II. Crystal structure of mitochondrial quinol-fumarate reductase from the parasitic nematode Ascaris suum.,Shimizu H, Osanai A, Sakamoto K, Inaoka DK, Shiba T, Harada S, Kita K J Biochem. 2012 Jun;151(6):589-92. Epub 2012 May 9. PMID:22577165 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Succinate Dehydrogenase

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