4f5e | pdb_00004f5e

Crystal structure of ERIS/STING

spinqualitylabelsall models 4f5e, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4f5e is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: EPE Related: 4f5d Gene: TMEM173, ERIS, MITA, STING (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed STING (stimulator of interferon genes) is an essential signaling adaptor that mediates cytokine production in response to microbial invasion by directly sensing bacterial secondary messengers such as the cyclic dinucleotide bis-(3'-5')-cyclic dimeric GMP (c-di-GMP). STING's structure and its binding mechanism to cyclic dinucleotides were unknown. We report here the crystal structures of the STING cytoplasmic domain and its complex with c-di-GMP, thus providing the structural basis for understanding STING function. The structural basis for the sensing and binding of cyclic di-GMP by STING.,Huang YH, Liu XY, Du XX, Jiang ZF, Su XD Nat Struct Mol Biol. 2012 Jun 24;19(7):728-30. doi: 10.1038/nsmb.2333. PMID:22728659 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Stimulator of interferon genes

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