3uw0 | pdb_00003uw0

Pectin methylesterase from Yersinia enterocolitica

spinqualitylabelsall models 3uw0, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3uw0 is a 1 chain structure with sequence from Yersinia enterocolitica subsp. enterocolitica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: YE0549 (Yersinia enterocolitica subsp. enterocolitica) Activity: Pectinesterase, with EC number 3.1.1.11 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Pectin methylesterases (PMEs) are family 8 carbohydrate esterases (CE8s) which remove the methyl group from methylesterified galacturonic acid (GalA) residues within pectin. Although the role of pectinases such as PMEs within dedicated phytopathogens has been well established, the significance of homologous enzymes found within the genomes of human enteropathogens remains to be determined. Presented here is the low-resolution (3.5 A) structure of the CE8 from Yersinia enterocolitica (YeCE8). The high degree of structural conservation in the topology of the active-site cleft and catalytic apparatus that is shared with a characterized PME from a bacterial phytopathogen (i) indicates that YeCE8 is active on methylated pectin and (ii) highlights a more prominent role for pectin utilization in Yersinia than in other enteropathogenic species. Structure of a pectin methylesterase from Yersinia enterocolitica.,Boraston AB, Abbott DW Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):129-33., Epub 2012 Jan 21. PMID:22297983 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Methylesterase

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