Saposin

Saposin (Sap) is a small protein which functions as activator of lipid-degrading enzymes. They act by isolating the lipid substrate from the membrane. Sap is synthesized as a precursor – prosaposin – which contain 4 SapB active domains and 2 SapA domains which are cleaved off. For more details see Molecular Playground/Saposin C.

3D Structures of Saposin

Updated on 10-December-2014

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• Saposin A
  • 2dob – hSapA residues 60-140 – human
    
  • 4ddj – hSapA + LDAO
    
• Saposin B
  • 1n69 – hSapB + lipid
• Saposin C
  • 1m12, 1sn6 – hSapC – NMR
    
  • 2gtg, 2qyp, 2z9a – hSapC residues 311-391
• Saposin D
  • 3bqp, 3bqq, 2r1q, 2rb3 - hSapD residues 405-484
    

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