4h4e | pdb_00004h4e

IspH in complex with (E)-4-mercapto-3-methylbut-2-enyl diphosphate

spinqualitylabelsall models 4h4e, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4h4e is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 10G, SF4 Related: 3ke8, 3dnf, 3f7t, 4h4c, 4h4d Gene: b0029, ispH, JW0027, lytB, yaaE (Escherichia coli K-12) Activity: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, with EC number 1.17.1.2 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The iron-sulfur protein IspH catalyzes a key step in isoprenoid biosynthesis in bacteria and malaria parasites. Crystal structures of IspH complexed with three substrate analogues reveal their mode of binding and suggest new routes to inhibitor design. Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe(4) S(4) ] Protein IspH.,Span I, Wang K, Wang W, Jauch J, Eisenreich W, Bacher A, Oldfield E, Groll M Angew Chem Int Ed Engl. 2013 Jan 10. doi: 10.1002/anie.201208469. PMID:23307751 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also 4-hydroxy-3-methylbut-2-enyl diphosphate reductase

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