1os2 | pdb_00001os2
Ternary enzyme-product-inhibitor complexes of human MMP12
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| 1os2, resolution 2.15Å | |||||||||||||
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| Ligands: | ZN, CA, ACT, AZI and HAE | ||||||||||||
| Gene: | MMP12 OR HME (Homo sapiens) | ||||||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Disease
Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]
About this Structure
1OS2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray structures of binary and ternary enzyme-product-inhibitor complexes of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, Angew Chem Int Ed Engl. 2003 Jun 16;42(23):2673-6. PMID:12813751
Page seeded by OCA on Thu Mar 20 13:14:53 2008
