4i7f | pdb_00004i7f

HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine

spinqualitylabelsall models 4i7f, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4i7f is a 2 chain structure with sequence from Hiv-1 m:b_hxb2r. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CL, MG, NVE, SO4 Gene: gag-pol, reverse transcriptase (HIV-1 M:B_HXB2R) Activity: RNA-directed DNA polymerase, with EC number 2.7.7.49 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed A series of nevirapine-based analogues containing the phosphonate functionality were prepared and evaluated in vitro against HIV RT. The effect of the phosphonate was evaluated against the wild type and Y181C HIV replication. An in vivo PK study was performed on a select analogue. Synthesis and biological evaluation of phosphonate analogues of nevirapine.,Parrish J, Tong L, Wang M, Chen X, Lansdon EB, Cannizzaro C, Zheng X, Desai MC, Xu L Bioorg Med Chem Lett. 2013 Mar 1;23(5):1493-7. doi: 10.1016/j.bmcl.2012.12.049., Epub 2012 Dec 21. PMID:23375792 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Reverse transcriptase

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