Template:STRUCTURE 2iik
Two different classes of thiolases are found . Degrative thiolase like 3-ketoacyl-CoA thiolase (KCT) is involved in fatty acid β oxidation. Biosynthetic thiolases like acetoacetyl-CoA thiolase (ACT) are involved in the thiolysis of acetoacetyl-CoA.
For Bacterial Thiolase see Bacterial thiolase
3D Structures of Thiolase
Updated on 11-December-2014
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- 3-ketoacyl-CoA thiolase
- 2wu9, 2c7y, 2c7z – KCT peroxisomal residues 36-462 – Arabidopsis thaliana
- 2wua - KCT peroxisomal residues 17-449 (mutant) – sunflower
- 2iik – hKCT peroximal - human
- 3goa – KCT – Salmonella typhimurium
- 1afw, 1pxt – yKCT peroxisomal - yeast
- 3w15 - yKCT peroxisomal residues 27-396 + peroxiomal membrane protein PEX21 + peroxisomal targeting signal receptor
- 2d3t – PfKCT + fatty oxidation complex β subunit – Pseudomonas fragi
- 1wdk, 1wdl, 1wdm - PfKCT + fatty oxidation complex α subunit
- Acetoacetyl-CoA thiolase
- 1m4s, 1m4t, 1dlu, 1qfl - ZrACT – Zoogloea ramigera
- 1dm3, 1dlv – ZrACT + CoA
- 2wku, 2wl6, 1m1t, 1m3k - ZrACT (mutant)
- 2wkt, 2wkv, 2wl4, 2wl5, 2vtz, 2vu0, 1m3z – ZrACT (mutant) + CoA
- 1m1o - ZrACT (mutant) + acetoacetyl-CoA
- 2vu0, 1nl7 - ZrACT + CoA
- 2vu1, 2vu2, 1ou6 - ZrACT + pantheteine-11-pivalate
- 2ib7, 2ib8, 2ib9, 2ibu, 2ibw, 2iby, 2f2s – hACT mitochondrial
- 1wl5 - hACT cytosolic
- 1wl4 – hACT cytosolic + CoA
- 4dd5, 4e1l – ACT – Clostridium difficile
