2hu4 | pdb_00002hu4

N1 neuraminidase in complex with oseltamivir 2

Loading... Status: waiting for Mol* initialization Structural highlights 2hu4 is a 8 chain structure with sequence from Influenza a virus. The May 2009 RCSB PDB Molecule of the Month feature on Influenza Neuraminidase by David Goodsell is 10.2210/rcsb_pdb/mom_2009_5. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: G39 Related: 2ht5, 2ht7, 2ht8, 2htu, 2htq, 2htv, 2htw, 2hty, 2htr, 2hu0 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design.,Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ Nature. 2006 Sep 7;443(7107):45-9. Epub 2006 Aug 16. PMID:16915235 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Avian Influenza Neuraminidase%2C Tamiflu and Relenza Eric Martz's Favorites Molecular Playground/Tamiflu Neuraminidase Teaching Scenes%2C Tutorials%2C and Educators' Pages

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