3i55 | pdb_00003i55

Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit

spinqualitylabelsall models 3i55, resolution 3.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3i55 is a 31 chain structure with sequence from Haloarcula marismortui and Haloarcula marismortui atcc 43049. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CD, CL, K, MG, MYL, NA, SR NonStd Res: 1MA, 2OP, 5AA, OMG, OMU, PO2, PSU, UR3 Related: 3i56 Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs. Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui.,Gurel G, Blaha G, Steitz TA, Moore PB Antimicrob Agents Chemother. 2009 Dec;53(12):5010-4. Epub 2009 Sep 8. PMID:19738021 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ribosome 3D structures

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