4aka | pdb_00004aka

IPSE alpha-1, an IgE-binding crystallin

spinqualitylabelsall models 4aka, 20 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4aka is a 1 chain structure with sequence from Schistosoma mansoni. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The interleukin-4-inducing principle from Schistosoma mansoni eggs (IPSE/alpha-1) is a major immunogenic component of schistosomes. It potently triggers the release of interleukin-4 from basophilic granulocytes in an IgE-dependent manner, suggesting a key function in the modulation of the host's immune response to Schistosoma mansoni infection. Here we present the near complete assignment of an IPSE/alpha-1 variant, IPSEDeltaNLS, which comprises the core domain of the protein. 1H, 13C and 15N chemical shift assignments of IPSEDeltaNLS.,Meyer NH, Schramm G, Sattler M Biomol NMR Assign. 2011 Oct;5(2):225-7. doi: 10.1007/s12104-011-9305-6. Epub 2011, Apr 24. PMID:21516468 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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