1pfz | pdb_00001pfz
PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM
| |||||||||||||
| 1pfz, resolution 1.85Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sites: | ASP | ||||||||||||
| Ligands: | GOL | ||||||||||||
| Activity: | Plasmepsin II, with EC number 3.4.23.39 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Overview
Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
About this Structure
1PFZ is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.
Reference
Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum., Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN, Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289
Page seeded by OCA on Thu Mar 20 13:23:50 2008
