2y96 | pdb_00002y96

STRUCTURE OF HUMAN DUAL-SPECIFICITY PHOSPHATASE 27

spinqualitylabelsall models 2y96, resolution 2.38Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2y96 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed There are over 100 genes in the human genome that encode protein tyrosine phosphatases (PTPs) and approximately 60 of these are classified as dual-specificity phosphatases (DUSPs). Although many dual-specificity phosphatases are still not well characterized, novel functions have been discovered for some of them that have led to new insights into a variety of biological processes and the molecular basis for certain diseases. Indeed, as the functions of DUSPs continue to be elucidated, a growing number of them are emerging as potential therapeutic targets for diseases such as cancer, diabetes and inflammatory disorders. Here, the overexpression, purification and structure determination of DUSP27 at 2.38 A resolution are presented. Structure of human dual-specificity phosphatase 27 at 2.38 A resolution.,Lountos GT, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):471-9. Epub 2011, Apr 16. PMID:21543850 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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