3j0c | pdb_00003j0c

Models of E1, E2 and CP of Venezuelan Equine Encephalitis Virus TC-83 strain restrained by a near atomic resolution cryo-EM map

spinqualitylabelsall models 3j0c, resolution 4.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3j0c is a 12 chain structure with sequence from Venezuelan equine encephalitis virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3j0g Activity: Togavirin, with EC number 3.4.21.90 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Venezuelan equine encephalitis virus (VEEV), a member of the membrane-containing Alphavirus genus, is a human and equine pathogen, and has been developed as a biological weapon. Using electron cryo-microscopy (cryo-EM), we determined the structure of an attenuated vaccine strain, TC-83, of VEEV to 4.4 A resolution. Our density map clearly resolves regions (including E1, E2 transmembrane helices and cytoplasmic tails) that were missing in the crystal structures of domains of alphavirus subunits. These new features are implicated in the fusion, assembly and budding processes of alphaviruses. Furthermore, our map reveals the unexpected E3 protein, which is cleaved and generally thought to be absent in the mature VEEV. Our structural results suggest a mechanism for the initial stage of nucleocapsid core formation, and shed light on the virulence attenuation, host recognition and neutralizing activities of VEEV and other alphavirus pathogens. 4.4 A cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus.,Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W EMBO J. 2011 Aug 9. doi: 10.1038/emboj.2011.261. PMID:21829169 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Virus coat protein

Proteopedia Page Contributors and Editors (what is this?)

OCA