3lpz | pdb_00003lpz

Crystal structure of C. therm. Get4

spinqualitylabelsall models 3lpz, resolution 1.98Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3lpz is a 1 chain structure with sequence from Chaetomium thermophilum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3iqw, 3iqx, 2wpv, 3lku Gene: Get4 (Chaetomium thermophilum) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Tail-anchored proteins play important roles in protein translocation, membrane fusion and apoptosis. They are targeted to the endoplasmic reticulum membrane via the guided-entry of tail-anchored proteins (Get) pathway. We present the 2A crystal structure of Get4 which participates in early steps of the Get pathway. The structure shows an alpha-solenoid fold with particular deviations from the regular pairwise arrangement of alpha-helices. A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway. The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis.,Bozkurt G, Wild K, Amlacher S, Hurt E, Dobberstein B, Sinning I FEBS Lett. 2010 Apr 16;584(8):1509-14. Epub 2010 Mar 3. PMID:20206626 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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