3onr | pdb_00003onr

Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379),from Mycobacterium tuberculosis with a novel calcium-binding site

spinqualitylabelsall models 3onr, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3onr is a 12 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CA, FMT, PT Gene: Rv0379, secE2 (Mycobacterium tuberculosis) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis identify the orthologs of Ca dodecins with different ligand-binding specificity. Crystal structure of the calcium chelating immunodominant antigen, calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.,Arockiasamy A, Aggarwal A, Savva CG, Holzenburg A, Sacchettini JC Protein Sci. 2011 Mar 2. doi: 10.1002/pro.607. PMID:21370306 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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