3q7k | pdb_00003q7k

Formate Channel FocA from Salmonella typhimurium

spinqualitylabelsall models 3q7k, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3q7k is a 10 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMT Gene: focA, STY0974, t1960 (Salmonella enterica subsp. enterica serovar Typhi) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The formate transporter FocA was described to switch its mode of operation from a passive export channel at high external pH to a secondary active formate/H(+) importer at low pH. The crystal structure of Salmonella typhimurium FocA at pH 4.0 shows that this switch involves a major rearrangement of the amino termini of individual protomers in the pentameric channel. The amino-terminal helices open or block transport in a concerted, cooperative action that indicates how FocA is gated in a pH-dependent way. Electrophysiological studies show that the protein acts as a specific formate channel at pH 7.0 and that it closes upon a shift of pH to 5.1. pH-dependent gating in a FocA formate channel.,Lu W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O Science. 2011 Apr 15;332(6027):352-4. PMID:21493860 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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