3vws | pdb_00003vws

Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107

spinqualitylabelsall models 3vws, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3vws is a 1 chain structure with sequence from Dengue virus 3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: PEG, VWS, ZN Activity: RNA-directed RNA polymerase, with EC number 2.7.7.48 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed We report a highly reproducible method to crystallize the RNA-dependent RNA polymerase (RdRp) domain of dengue virus serotype-3 (DENV-3), allowing structure refinement to 1.79 A resolution and revealing amino acids not seen previously. We also present a DENV-3 polymerase/inhibitor co-crystal structure at 2.1 A resolution. The inhibitor binds to the RdRp as a dimer and causes conformational changes in the protein. The improved crystallization conditions and new structural information should accelerate structure-based drug discovery. Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor.,Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY J Virol. 2013 Feb 13. PMID:23408636 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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