4fpp | pdb_00004fpp

Bacterial phosphotransferase

spinqualitylabelsall models 4fpp, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4fpp is a 3 chain structure with sequence from Caulobacter crescentus cb15. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, MG, NI Gene: CC_3470 (Caulobacter crescentus CB15) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Two-component and phosphorelay signal-transduction proteins are crucial for bacterial cell-cycle regulation in Caulobacter crescentus. ChpT is an essential histidine phosphotransferase that controls the activity of the master cell-cycle regulator CtrA by phosphorylation. Here, the 2.2 A resolution crystal structure of ChpT is reported. ChpT is a homodimer and adopts the domain architecture of the intracellular part of class I histidine kinases. Each subunit consists of two distinct domains: an N-terminal helical hairpin domain and a C-terminal alpha/beta domain. The two N-terminal domains are adjacent within the dimer, forming a four-helix bundle. The ChpT C-terminal domain adopts an atypical Bergerat ATP-binding fold. Structural insights into ChpT, an essential dimeric histidine phosphotransferase regulating the cell cycle in Caulobacter crescentus.,Fioravanti A, Clantin B, Dewitte F, Lens Z, Verger A, Biondi EG, Villeret V Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Sep 1;68(Pt 9):1025-9., doi: 10.1107/S1744309112033064. Epub 2012 Aug 29. PMID:22949187 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Phosphotransferase

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