4gkv | pdb_00004gkv

Structure of Escherichia coli AdhP (ethanol-inducible dehydrogenase) with bound NAD

spinqualitylabelsall models 4gkv, resolution 2.01Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4gkv is a 5 chain structure with sequence from Escherichia coli and Escherichia coli k-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GOL, NAD, ZN Gene: adhP, yddN, b1478, JW1474 (Escherichia coli K-12) Activity: Alcohol dehydrogenase, with EC number 1.1.1.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The crystal structure of AdhP, a recombinantly expressed alcohol dehydrogenase from Escherichia coli K-12 (substrain MG1655), was determined to 2.01 A resolution. The structure, which was solved using molecular replacement, also included the structural and catalytic zinc ions and the cofactor nicotinamide adenine dinucleotide (NAD). The crystals belonged to space group P21, with unit-cell parameters a = 68.18, b = 118.92, c = 97.87 A, beta = 106.41 degrees . The final R factor and Rfree were 0.138 and 0.184, respectively. The structure of the active site of AdhP suggested a number of residues that may participate in a proton relay, and the overall structure of AdhP, including the coordination to structural and active-site zinc ions, is similar to those of other tetrameric alcohol dehydrogenase enzymes. Structure of Escherichia coli AdhP (ethanol-inducible dehydrogenase) with bound NAD.,Thomas LM, Harper AR, Miner WA, Ajufo HO, Branscum KM, Kao L, Sims PA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jul 1;69(Pt 7):730-2. doi:, 10.1107/S1744309113015170. Epub 2013 Jun 27. PMID:23832197 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Alcohol dehydrogenase

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