4ggm | pdb_00004ggm

Structure of LpxI

spinqualitylabelsall models 4ggm, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ggm is a 1 chain structure with sequence from Caulobacter crescentus na1000. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: LP5, MG NonStd Res: MSE Related: 4ggi Gene: 7330127, CCNA_01987, lpxI (Caulobacter crescentus NA1000) Activity: UDP-2,3-diacylglucosamine diphosphatase, with EC number 3.6.1.54 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Enzymes in lipid metabolism acquire and deliver hydrophobic substrates and products from within lipid bilayers. The structure at 2.55 A of one isozyme of a constitutive enzyme in lipid A biosynthesis, LpxI from Caulobacter crescentus, has a novel fold. Two domains close around a completely sequestered substrate, UDP-2,3-diacylglucosamine, and open to release products either to the neighboring enzyme in a putative multienzyme complex or to the bilayer. Mutation analysis identifies Asp225 as key to Mg(2+)-catalyzed diphosphate hydrolysis. These structures provide snapshots of the enzymatic synthesis of a critical lipid A precursor. LpxI structures reveal how a lipid A precursor is synthesized.,Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM Nat Struct Mol Biol. 2012 Nov;19(11):1132-8. doi: 10.1038/nsmb.2393. Epub 2012, Oct 7. PMID:23042606 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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