4ilu | pdb_00004ilu

Crystal structure of Mycobacterium tuberculosis CarD

spinqualitylabelsall models 4ilu, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ilu is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: SO4 Related: 4mfr Gene: carD, MT3689, Rv3583c (Mycobacterium tuberculosis) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Mycobacterium tuberculosis (Mtb) CarD is an essential transcriptional regulator that binds RNA polymerase and plays an important role in reprogramming transcription machinery under diverse stress conditions. Here, we report the crystal structure of CarD at 2.3 A resolution, that represents the first structural description of CarD/CdnL-Like family of proteins. CarD adopts an overall bi-lobed structural architecture where N-terminal domain resembles 'tudor-like' domain and C-terminal domain adopts a novel five helical fold that lacks the predicted leucine zipper structural motif. The structure reveals dimeric state of CarD resulting from beta-strand swapping between the N-terminal domains of each individual subunits. The structure provides crucial insights into the possible mode(s) of CarD/RNAP interactions. Proteins 2013; (c) 2013 Wiley Periodicals, Inc. Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture.,Kaur G, Dutta D, Thakur KG Proteins. 2013 Sep 30. doi: 10.1002/prot.24419. PMID:24115125 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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