4hfu | pdb_00004hfu

Crystal structure of Fab 8M2 in complex with a H2N2 influenza virus hemagglutinin

spinqualitylabelsall models 4hfu, resolution 3.11Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4hfu is a 4 chain structure with sequence from Homo sapiens and Influenza a virus (a/japan/305+/1957(h2n2)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: NAG Related: 4hg4 Gene: HA (Influenza A virus (A/Japan/305+/1957(H2N2))) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Influenza virus hemagglutinin (HA) mediates receptor binding and viral entry during influenza infection. The development of receptor analogs as viral-entry blockers has not been successful, which suggests that sialic acid may not be an ideal scaffold to obtain broad, potent HA inhibitors. Here, we report crystal structures of Fab fragments from three human antibodies that neutralize the 1957 pandemic H2N2 influenza virus in complex with H2 HA. All three antibodies use an aromatic residue to plug a conserved cavity in the HA receptor-binding site. Each antibody interacts with the absolutely conserved HA1 Trp153 at the cavity base through pi-pi stacking with the signature Phe54 of two VH1-69-encoded antibodies or a tyrosine from HCDR3 in the other antibody. This highly conserved interaction can be used as a starting point to design inhibitors targeting this conserved hydrophobic pocket in influenza viruses. A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin.,Xu R, Krause JC, McBride R, Paulson JC, Crowe JE Jr, Wilson IA Nat Struct Mol Biol. 2013 Mar;20(3):363-70. doi: 10.1038/nsmb.2500. Epub 2013 Feb, 10. PMID:23396351 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Hemagglutinin

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