1sac | pdb_00001sac
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| 1sac, resolution 2.0Å | |||||||||||||
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| Ligands: | CA and ACY | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT
Overview
The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
Disease
Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]
About this Structure
1SAC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934
Page seeded by OCA on Thu Mar 20 14:02:25 2008
