4lvp | pdb_00004lvp

Crystal structure of IFT81 N-terminal domain

spinqualitylabelsall models 4lvp, resolution 2.32Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4lvp is a 1 chain structure with sequence from Chlamydomonas reinhardtii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: TA0 Related: 4lvr Gene: IFT81, CHLREDRAFT_138649 (Chlamydomonas reinhardtii) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells. However, the molecular mechanisms of IFT are poorly understood. Here, we found that the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. Knockdown of IFT81 and rescue experiments with point mutants showed that tubulin binding by IFT81 was required for ciliogenesis in human cells. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.,Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E Science. 2013 Aug 30;341(6149):1009-12. doi: 10.1126/science.1240985. PMID:23990561 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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