4k7e | pdb_00004k7e

Crystal structure of Junin virus nucleoprotein

spinqualitylabelsall models 4k7e, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4k7e is a 1 chain structure with sequence from Junin virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: N (Junin virus) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Junin virus (JUNV) is identified as the etiological agent of Argentine hemorrhagic fever (AHF), which leads to a serious public health problem with approximately five million people at risk. It is treated as a potential bioterrorism agent for its rapid transmission by aerosols. JUNV is a negative-sense single-stranded RNA (-ssRNA) virus that belongs to the genus Arenavirus within the family Arenaviridae and its genomic RNA contains two segments encoding four proteins. Among these proteins, the nucleoprotein (NP) has essential roles in viral RNA synthesis and immune suppression, but the molecular mechanisms are only partially understood. Here, we represent a 2.2 A crystal structure of the C-terminal domain of JUNV NP. This structure shows high similarity with the Lassa fever virus (LASV) NP C-terminal domain. However, both the structure and function show differences compare to the LASV NP. This study extends our structural insight into the -ssRNA virus nucleoproteins. Crystal structure of Junin virus nucleoprotein.,Zhang Y, Li L, Liu X, Dong S, Wang W, Huo T, Guo Y, Rao Z, Yang C J Gen Virol. 2013 Jul 24. PMID:23884367 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein

Proteopedia Page Contributors and Editors (what is this?)

OCA