4kwe | pdb_00004kwe

GDP-bound, double-stranded, curved FtsZ protofilament structure

spinqualitylabelsall models 4kwe, resolution 2.91Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4kwe is a 3 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: GDP Gene: ftsZ, MT2209, MTCY270.18, Rv2150c (Mycobacterium tuberculosis) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring". During cytokinesis, the Z ring exerts a constrictive force on the membrane by using the chemical energy of guanosine triphosphate hydrolysis. However, the structural basis of this constriction remains unresolved. Here, we present the crystal structure of a guanosine diphosphate-bound Mycobacterium tuberculosis FtsZ protofilament, which exhibits a curved conformational state. The structure reveals a longitudinal interface that is important for function. The protofilament curvature highlights a hydrolysis-dependent conformational switch at the T3 loop that leads to longitudinal bending between subunits, which could generate sufficient force to drive cytokinesis. FtsZ protofilaments use a hinge-opening mechanism for constrictive force generation.,Li Y, Hsin J, Zhao L, Cheng Y, Shang W, Huang KC, Wang HW, Ye S Science. 2013 Jul 26;341(6144):392-5. doi: 10.1126/science.1239248. PMID:23888039 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cell division protein Ftsz Tubulin

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