1gcn | pdb_00001gcn

X-RAY ANALYSIS OF GLUCAGON AND ITS RELATIONSHIP TO RECEPTOR BINDING

spinqualitylabelsall models 1gcn, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 1gcn is a 1 chain structure with sequence from Sus scrofa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed X-ray analysis of the pancreatic hormone glucagon shows that in crystals the polypeptide adopts a mainly helical conformation, which is stabilised by hydrophobic interactions between molecules related by threefold symmetry. A model is presented in which the glucagon molecule exists in dilute solutions as an equilibrium population of conformers with little retention of conformers with little retention of structure, and in which the helical conformation is stablised by hydrophobic interactions either as an oligomer or as a complex with the receptor. X-ray analysis of glucagon and its relationship to receptor binding.,Sasaki K, Dockerill S, Adamiak DA, Tickle IJ, Blundell T Nature. 1975 Oct 30;257(5529):751-7. PMID:171582 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glucagon

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