4ajm | pdb_00004ajm

Development of a plate-based optical biosensor methodology to identify PDE10 fragment inhibitors

spinqualitylabelsall models 4ajm, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ajm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: 3A6, MG, ZN Related: 1lrb, 2wey, 2y0j, 4ael, 4ajd, 4ajf, 4ajg Resources: FirstGlance, OCA, RCSB, PDBsum Function [PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. See Also Phosphodiesterase

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